Does high-dose omega-3 fight atrophy? (5g/day) | Dr. Chris McGlory
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In a study led by Dr. Chris McGlory, young women were given 5 grams of omega-3 fatty acids daily for four weeks before wearing a leg brace for two weeks to simulate immobilization. The results showed that the omega-3s significantly reduced muscle loss. This muscle-protective effect is thought to arise from omega-3s' ability to enhance muscle protein synthesis by improving the body's responsiveness to amino acids, with anti-inflammatory properties potentially contributing as well. These benefits may be particularly important for older adults who are susceptible to muscle wasting during periods of inactivity or immobilization. In this clip, Dr. McGlory discusses the potential of omega-3 fatty acids to protect against muscle loss during periods of immobilization or inactivity.
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The shrinking or wasting away of cells, organs, or tissues that may occur as part of a disease process, trauma, or aging.
Amino acids that cannot be synthesized by the organism, but must be supplied via diet. The nine amino acids humans cannot synthesize are phenylalanine, valine, threonine, tryptophan, methionine, leucine, isoleucine, lysine, and histidine.
A multifunctional protein that facilitates the transport of large neutral amino acids such as leucine into muscle cells, thereby stimulating protein synthesis and anabolic signaling.[1] LAT1 expression is upregulated during the progression of several types of cancer.[2] It also carries some drugs and prodrugs across the blood-brain barrier and may provide an effective drug-delivery mechanism for various neurodegenerative disorders.[3]
- ^ Hodson, Nathan; Brown, Thomas; Joanisse, Sophie; Aguirre, Nick; West, Daniel; Moore, Daniel, et al. (2017). Characterisation Of L-Type Amino Acid Transporter 1 (LAT1) Expression In Human Skeletal Muscle By Immunofluorescent Microscopy Nutrients 10, 1.
- ^ Salisbury, Travis; Arthur, Subha (2018). The Regulation And Function Of The L-Type Amino Acid Transporter 1 (LAT1) In Cancer International Journal Of Molecular Sciences 19, 8.
- ^ Huttunen, Johanna; Peltokangas, Soile; Gynther, Mikko; Natunen, Teemu; Hiltunen, Mikko; Auriola, Seppo, et al. (2019). l-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve The Delivery Of Drugs Into Neurons, Astrocytes And Microglia Scientific Reports 9, 1.
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