Joe Rogan Experience #1178 - Dr. Rhonda Patrick

Posted on October 2nd 2018 (over 6 years)

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Dr. Rhonda Patrick makes her eighth appearance on the Joe Rogan Experience.

A few of the topics and studies mentioned in this episode include...

  • BPA in plastic bottles is a potential endocrine disruptor. Study.
  • BPA has diverse effects on human health, including endocrine, reproductive, and transgenerational epigenetic effects. Study.
  • BPA alters insulin sensitivity. Study.
  • BPA interferes with in vitro fertilization. Study.
  • BPA transfers across placenta: Study.
  • BPA leaches out of baby bottles with repeated use. Study.
  • Carnivore diet
  • People consume less when following a low carb, high protein diet. Study.
  • Diet monotony induces food habituation and decreases food intake. Study.
  • Fasting-mimicking diet and ketogenic diet improve symptoms of multiple sclerosis. Study.
  • Profound changes in gut microbiome occur with intermittent fasting. Study.
  • Minocycline, a type of antibiotic, relieved symptoms of multiple sclerosis due to alterations in gut microbiome. Study.
  • The gut microbiome plays key roles in human health and disease. Study.
  • When people change from a high fiber to a high protein diet, their gut microbiome undergoes rapid and dramatic change. Study.
  • “Putrefactive” bacteria in gut metabolize amino acids and are linked with increased risk of colon cancer. Study.
  • Fasting favorably alters the gut microbiome. Study.
  • Organs shrink during fasting and then regrow after refeeding. Study.
  • Fasting stresses healthy cells so they increase their stress-response pathways, including heat shock proteins, antioxidant production, and anti-inflammatory. Study.
  • Ketogenic diet improves symptoms in people with autoimmune disease. Study.
  • The placebo and nocebo effect has a genetic basis. Study.
  • Placebo/nocebo effect seen in gluten sensitivity studies. Study.
  • Dietary fish oil increases dopamine production in brain. Study.
  • How the RDAs - Recommended Dietary Allowances - are set: randomized controlled and non-randomized controlled trials, and depletion-repletion, balance, cross-sectional, and case studies. Study.
  • Carnivore diet deficiency: Vitamin C
  • Vitamin C and glucose use different transporters to enter cells. Study
  • RDA for vitamin C based on depletion-repletion studies. Study.
  • There’s a lot of biological variation in vitamin C needs. Study.
  • Carnivore diet deficiency: Vitamin E
  • RDA for vitamin E based on its ability to maintain cell integrity. Study.
  • Men on low vitamin E diet showed hemolysis of their red blood cells after 2.5 years. Study.
  • Inadequate folate causes double-stranded breaks in DNA. Study.
  • Lack of consumer tests available for measuring DNA damage accurately
  • Phytochemicals as activators of beneficial stress response and evolutionary context.
  • Sulforaphane
  • Broccoli sprouts have 10 to 100 times more sulforaphane than mature broccoli. Isothiocyanate facts.
  • Sulforaphane promotes urinary excretion of benzene and acrolein, compounds in air pollution. Study.
  • Sulforaphane activates Phase II detoxification enzymes and deactivates Phase I biotransformation enzymes, which can convert compounds to carcinogens. Study.
  • Sulforaphane lowers biomarker for prostate cancer 86%. Study.
  • Sulforaphane in Brussels sprouts increases antioxidant compound glutathione. Study.
  • Sulforaphane in brussels sprouts decreases oxidative DNA damage. Study.
  • Sulforaphane increases antioxidant compound glutathione in human brain. Study.
  • Major changes in diet can alter the gut microbiome and temporarily cause discomfort
  • Fasting and the fasting-mimicking diet
  • Types of Alzheimer’s disease and current status of research
  • APOE4 as a genetic risk factor for Alzheimer’s disease
  • Amyloid plaques in brain are cleared away during sleep. Study.
  • People who have APOE4 have a reduced efficiency of amyloid clearance. Study.
  • Faulty DHA transport system in brains of people with APOE4 can be bypassed with phospholipid form of DHA. Study.
  • Fish oil lowered cardiovascular disease risk by ~30%. Study.
  • Ketones and Ketosis
  • Sulforaphane supplementation
  • Parenthood
  • Health benefits of heat stress
  • Single episode of sauna use improves vascular compliance (blood vessels’ ability to contract and expand), reduces blood pressure, and decreases CRP. Study.
  • Sauna stimulates mitochondrial biogenesis in muscle. Study.
  • Sauna use may reduce a chronic inflammatory state by reducing inflammatory cytokines. Study.
  • Sauna use before working out reduces delayed-onset muscle soreness associated with exercise. Study.
  • Increasing core body temperature decreases symptoms of depression. Dr. Raison study.
  • Taking NSAIDs before working out blunts some of the benefits derived from exercise. Study.
  • Effects of sensory deprivation

Scientists mentioned

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