Does omega-3 reduce muscle loss from cancer? | Dr. Chris McGlory
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High levels of inflammation can negatively affect protein synthesis in muscle by influencing certain initiation factors, thus potentially contributing to muscle atrophy. This is especially relevant in conditions like sarcopenia and cancer cachexia, where inflammation plays a significant role. Emerging evidence suggests that omega-3 fatty acids, especially EPA, might help mitigate muscle loss in cancer patients and could potentially protect against the detrimental effects of chemotherapy on muscle. In this clip, Dr. Chris McGlory discusses the potential role of omega-3 fatty acids in muscle health, especially in the context of cancer cachexia.
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The shrinking or wasting away of cells, organs, or tissues that may occur as part of a disease process, trauma, or aging.
A complex wasting disorder characterized by extreme muscle mass loss, with or without fat mass loss. The pathophysiology of cachexia is multifactorial and may include factors that promote increased metabolic rate and energy expenditure, reduced nutrient intake or availability, increased muscle breakdown, and the inhibition of muscle growth. Cachexia is a common feature of advanced cancer, but it is also associated with other chronic diseases, including chronic obstructive pulmonary disease, heart failure, kidney disease, and inflammatory diseases, including AIDS.[1]
A critical element of the body’s immune response. Inflammation occurs when the body is exposed to harmful stimuli, such as pathogens, damaged cells, or irritants. It is a protective response that involves immune cells, cell-signaling proteins, and pro-inflammatory factors. Acute inflammation occurs after minor injuries or infections and is characterized by local redness, swelling, or fever. Chronic inflammation occurs on the cellular level in response to toxins or other stressors and is often “invisible.” It plays a key role in the development of many chronic diseases, including cancer, cardiovascular disease, and diabetes.
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