High intake of carbohydrates linked with all cause mortality | Eric Verdin
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The insulin signaling pathway is one of the major pathways that control aging. Researchers have demonstrated in numerous animal models that higher insulin production leads to faster aging. Recent human studies indicate that the fewer carbohydrates one eats, the lower the risk of death from all causes. In this clip, Dr. Eric Verdin explains the importance of the insulin signaling pathway in aging and highlights both animal and human research in this area.
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The death rate from all causes of death for a population in a given time period.
A transparent nematode species (a type of roundworm), about 1mm in length. The first multicellular organism to have its whole genome sequenced. Because they have a short lifespan (about 14-15 days), they are a good model organism for aging research. Strains are inexpensive to breed and can be frozen. When subsequently thawed, they remain viable, allowing long-term storage.
A genus of flies, often called "fruit flies," that has been heavily used in research in genetics and is a common model organism in developmental biology. Fruit flies are popular experimental animals because they are easily cultured en masse out of the wild, have a short generation time, and mutants are readily obtainable.
A peptide hormone secreted by the beta cells of the pancreatic islets cells. Insulin maintains normal blood glucose levels by facilitating the uptake of glucose into cells; regulating carbohydrate, lipid, and protein metabolism; and promoting cell division and growth. Insulin resistance, a characteristic of type 2 diabetes, is a condition in which normal insulin levels do not produce a biological response, which can lead to high blood glucose levels.
The three basic components of the human diet. Macronutrients are consumed in large quantities and provide necessary energy for the body. They include carbohydrates, fats, and proteins.
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