Cyclic ketogenic diet improved healthspan and improved memory in mice | Eric Verdin
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When researchers fed mice a ketogenic diet, the mice gained weight. To overcome this weight gain, investigators cycled the ketogenic diet on and off, and the mice maintained a stable weight. When on a cyclic ketogenic diet, the researchers observed that mice had an increased median lifespan and improved memory. A separate group of investigators, using a portion-controlled ketogenic diet showed similar results. The mice on the portion-controlled ketogenic diet did even better, suggesting that the cyclic nature may be somewhat stressful for the animals. In this clip, Dr. Eric Verdin explains how a cyclic or the portion-controlled ketogenic diet is linked to improvements in lifespan and memory in mice.
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The practice of long-term restriction of dietary intake, typically characterized by a 20 to 50 percent reduction in energy intake below habitual levels. Caloric restriction has been shown to extend lifespan and delay the onset of age-related chronic diseases in a variety of species, including rats, mice, fish, flies, worms, and yeast.
The years of a person’s life spent free of disease.
A diet that causes the body to oxidize fat to produce ketones for energy. A ketogenic diet is low in carbohydrates and high in proteins and fats. For many years, the ketogenic diet has been used in the clinical setting to reduce seizures in children. It is currently being investigated for the treatment of traumatic brain injury, Alzheimer's disease, weight loss, and cancer.
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