Growth hormone defect protects against cancer, diabetes, and cognitive decline | Valter Longo
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Similar in molecular structure to insulin, IGF-1 (insulin-like growth factor 1) has been implicated in the aging process. Protein intake increases IGF-1 levels in humans, independent of total caloric consumption. IGF-1 participates in a complex pathway known as the growth hormone/IGF-1 axis, where it exerts its role to accelerate aging. In this clip, Dr. Valter Longo explains how certain macronutrients influence the insulin/IGF-1/growth hormone axis to modulate aging in many cell types.
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One of the most potent natural activators of the AKT signaling pathway. IGF-1 stimulates cell growth and proliferation, inhibits programmed cell death, mediates the effects of growth hormone, and may contribute to aging and enhancing the growth of cancer after it has been initiated. Similar in molecular structure to insulin, IGF-1 plays a role in growth during childhood and continues later in life to have anabolic, as well as neurotrophic effects. Protein intake increases IGF-1 levels in humans, independent of total caloric consumption.
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