Going beyond CRISPR with 1 million edits per cell │ Dr. George Church
No media content.
Get the full length version of this episode as a podcast.
This episode will make a great companion for a long drive.
The BDNF Protocol Guide
An essential checklist for cognitive longevity — filled with specific exercise, heat stress, and omega-3 protocols for boosting BDNF. Enter your email, and we'll deliver it straight to your inbox.
CRISPR-Cas9 is a system of gene editing that has revolutionized how scientists engineer cells over the past decade. Before CRISPR, homologous recombination and single-stranded DNA annealing proteins (SSAPs) enabled early gene editing, but what comes next? Deaminases, transposonases, and more sophisticated SSAPs are able to deliver gene therapies with more precision than CRISPR.
Multiplex editing allows geneticists to make multiple genome alterations at once. Using this amazing technology, humanized organs from large mammals like pigs will enable organ transplantation on demand instead of patients waiting for years for a donor. Base editing in humans may facilitate gene therapies that eliminate common diseases of aging such as high cholesterol. Unlike antibody treatments that target the PCSK9 protein (an important regulator of blood cholesterol levels), which are very expensive, base editing could deliver permanent protection from hypercholesterolemia with just one dose. In this clip, Dr. George Church shares insights on the future of gene therapies in healthcare.
This transcript is reserved for members.
FoundMyFitness Members get access to exclusive content not available anywhere else, including a transcript of this episode.
You wouldn't believe how cool being a premium member of the world's best cross-disciplinary science-focused website and podcast really is.
Member only extras:
Learn more about the advantages of a premium membership by clicking below.
Hear new content from Rhonda on The Aliquot, our member's only podcast
Listen in on our regularly curated interview segments called "Aliquots" released every week on our premium podcast The Aliquot. Aliquots come in two flavors: features and mashups.
- Hours of deep dive on topics like fasting, sauna, child development surfaced from our enormous collection of members-only Q&A episodes.
- Important conversational highlights from our interviews with extra commentary and value. Short but salient.
Genetic engineering News
- CRISPR gene editing successfully stopped the progression of Duchenne muscular dystrophy in dogs. It restored muscle function in their hearts & more.
- New gene-editing CRISPR technique successfully corrected mutations in the gene that causes Duchenne muscular dystrophy in heart muscle cells.
- Hacking Your Genes Has Never Been Easier
- Reprogrammed skin cells shrink brain tumors in mice.
- Is Unregulated Biohacking the Future of Science? The $140 Mail-Order CRISPR Kit
