Aliquot #91: How blood-brain barrier dysfunction fuels Alzheimer's disease
Aliquot #91: How blood-brain barrier dysfunction fuels Alzheimer's disease
The blood-brain barrier is a collection of membranes that separate the central nervous system from the circulatory system. It permits the passage of nutrients and other beneficial molecules from the bloodstream into the brain while excluding harmful ones. Genetic predisposition, altered glucose uptake in the brain, high blood pressure, and other factors can weaken the barrier's integrity, allowing endotoxins and inflammatory immune cells to infiltrate the brain and increasing a person's risk for dementia.
Get these episodes in a convenient podcast format.
Aliquot episodes make great companion listening for a long drive. You can find these special members-only episodes alongside live recorded Q&As on The Aliquot, our official premium FoundMyFitness podcast.
The blood-brain barrier is a collection of membranes that separate the central nervous system from the circulatory system. It permits the passage of nutrients and other beneficial molecules from the bloodstream into the brain while excluding harmful ones. Genetic predisposition, altered glucose uptake in the brain, high blood pressure, and other factors can weaken the barrier's integrity, allowing endotoxins and inflammatory immune cells to infiltrate the brain and increasing a person's risk for dementia.
In this Aliquot, Dr. Axel Montagne and I discuss factors that weaken the blood-brain barrier.
-
The impact of a compromised blood-brain barrier
-
The Interplay of APOE4 and Cyclophilin A
-
Why APOE4 compromises the blood-brain barrier
-
Is there already a drug that might reduce the damage?
-
Implications for the glymphatic system and toxin clearance
-
How faulty glucose transport in the brain plays a role in Alzheimer's
-
Why low omega-3 may impair glucose transporter function
-
What's the role of hypertension in dementia?
-
Lifestyle approaches to blood pressure and dementia
Get email updates with the latest curated healthspan research
Support our work
Every other week premium members receive a special edition newsletter that summarizes all of the latest healthspan research.
Recent Aliquot Episodes
Aliquot #124: How much sodium do you actually need?
In this Aliquot, I explore how genetics, lifestyle, and potassium balance influence sodium's role in...
Aliquot #123: Diet & Lifestyle Strategies for Optimizing Eye Health
In this Aliquot, you'll hear expert insights from Drs. Bruce Ames, Andrew Huberman, Axel Montagne, and me...
Aliquot #122: How to Limit Microplastic Exposure
In this Aliquot, I briefly describe the science and concerns surrounding microplastics and identify ways to lessen...
Aliquot #121: Harnessing Natural Light for Better Sleep
In this Aliquot, Drs. Matt Walker, Satchin Panda, and Andrew Huberman explore how to harness the benefits of natural light...
Aliquot #120: How the Experts Build Muscle Mass
In this Aliquot, we explore strategies for optimizing muscle mass through exercise, nutrition, and supplements with...