How loss of dopamine-producing neurons affects brain circuitry and behavior | Giselle Petzinger

Posted on October 27th 2020 (over 4 years)

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Diagnosis of Parkinson's disease occurs at the onset of motor symptoms when half or more of the brain's dopamine-producing neurons are lost. Dopaminergic neurons are lost initially in the motor circuit of the brain, known as the basal ganglia, which is responsible for automatic movements, for example, balance. People with PD report that they compensate for this loss by "thinking more" about their movements. However, as the disease progresses additional brain circuits are involved, and this compensation is no longer possible - leading to falls. In this clip, Dr. Giselle Petzinger explains how the loss of dopamine disrupts circuitry in the brains of people with Parkinson's disease.

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