How folate deficiency leads to DNA damage similar to being irradiated | Bruce Ames
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In this clip, Bruce Ames describes how folate is critical for the transferring of single-carbon groups between molecules. A deficiency in folate leads to errors in production of nucleic acids and can lead to double-stranded breaks in DNA. Radiation also induces double-stranded breaks but through a different mechanism. Either way, both folate deficiency and radiation lead to increased cell death and accelerated aging.
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