This episode will make a great companion for a long drive.
An essential checklist for cognitive longevity — filled with specific exercise, heat stress, and omega-3 protocols for boosting BDNF. Enter your email, and we'll deliver it straight to your inbox.
COVID-19 mRNA vaccines consist of a small piece of mRNA protected by a lipid droplet that is injected into the deltoid muscle of the arm. The spike protein is made and expressed on the cell's surface where it remains until it is detected by the immune system. There has been some concern — stemming from studies in rodents given massive doses — that vaccine nanoparticles can exit the deltoid muscle and travel to other organs. When researchers gave rats a human-equivalent dose no vaccine particles were observed after 48 hours. Furthermore, these initial studies did not distinguish between intact vaccine particles, remnants, or merely tagging molecules. In this clip, Dr. Rhonda Patrick discusses whether mRNA COVID-19 vaccines spread to different organs.
Dr. Patrick: But people are concerned that these mRNA vaccines are getting into multiple organs, and therefore the spike protein is getting into these other organs and causing damage, again, different spike protein. So, that needs to be considered. But a lot of this data stems from...a lot of this concern stems from some data that was generated by Pfizer and BioNTech when they were doing a bunch of safety studies looking at, you know, what happens when you inject really high concentrations of the mRNA vaccine by Pfizer into rodents. And so, I think, the first thing to keep in mind...and I know that at MedCram, you guys have had people on like Dr. Shane Crotty who's explained how the mRNA vaccines work, how you have, you know, the mRNA inside of a lipid nanoparticle along with some other factors like polyethylene glycol, and that is injected into the deltoid muscle tissue, and that basically, after that injection into the tissue happens, you have the lipid nanoparticle with the mRNA vaccine now getting inside of muscle cells using your own cell machinery, the ribosome, to actually make the spike protein, which itself has been shown to peak after 24 hours, and then after 48 hours, the spike protein, half-life of the protein that's made is degraded. It's not very long-lasting. The mRNA itself also has a half-life somewhere between, you know, 48 to 72 hours, and the lipid nanoparticle has a very short...like within hours. It really only lasts long enough to protect the mRNA from being degraded. But once you actually do make the spike protein, the spike protein itself is...it is expressed on the cell surface, what's called the plasma membrane of the cell. And the spike protein itself has a region on it called a transmembrane domain that sticks it. It's like an anchored...anchors into that plasma membrane, so it is not freely floating out into your circulation. It is stuck there. And at that point, you have other immune cells that recognize this foreign protein and begin the process of, you know, making antibodies, and you have that whole, you know, immunity effect.
But the concern was from this Pfizer study where rats were given a dose that is 10 times the amount of what humans are given. So humans are given 30 micrograms of the Pfizer-BioNTech vaccine for one dose. The rat was given 50 micrograms of the Pfizer-BioNTech vaccine. So, if you were to do the calculation for a rat equivalent dose, so if you want to give the rat what humans actually get, an equivalent dose based on their body mass, it would be more like 4.86 micrograms. So they got 50. That's essentially 10 times. Okay. And this was done for a reason of, "Okay, what happens when we give them a huge amount of the vaccine?" Well, what was found...the lipid nanoparticle that contains the mRNA was radio-labeled. It's like a tag that you can visualize things. And that radio-labeled tag was found in other organs. It was, you know, found in a variety of organs. Again, it was to a very small degree, but it was found in other organs. And so people got really concerned that these mRNA vaccines were traveling to other organs and causing damage. And a few things to keep in mind there. One, the dose was super high, and, in fact, within the same document, the same Pfizer study, they gave a more equivalent dose to mice. In this case, they give mice 2 micrograms of the mRNA vaccine, and that vaccine did not go to all these other organs. In fact, the only organ that was shown to have any amount of this radio-labeled tag was the liver, and it was completely gone after 48 hours. And so, I think, that's really good news because it suggests, yeah, when you give, you know, a rat 10 times the amount of what the humans are getting, you might have some spillover. But on top of that, again, the radio-labeled tag that we're looking at is the lipid nanoparticle, and if there is some spillover, you know, in the muscle tissue, what surrounds the muscle tissue is your lymphatic system, lymph, where all the immune cells are. So you essentially have your immune cells like dendritic cells recognizing something foreign, in this case, a radio-labeled lipid nanoparticle with some mRNA in it, and they basically chop it up, and, you know, it undergoes phagocytosis and is taken to other tissues for recycling. And so, whatever we're seeing in those other organs, we don't even actually know if that's, you know, the intact mRNA vaccine lipid nanoparticles. It's probably just remnants of it because that's what your body does.
So, I think, all of those factors in combination give some reassurance that people should not be so concerned about the spike protein from mRNA vaccines or from the Johnson & Johnson vaccine getting to other organs and causing...you know, wreaking havoc essentially.
And I will just add one more thing to that, and that is another study, and this is something that I've seen concern about on the internet. This study was done in humans. It was a very, very small sample size. It was 13 people, and they were given the Moderna mRNA vaccine. What was found in that study is that 11 out of 13 people, the S1 subunit of the spike protein was detected in their plasma. Three out of the 13 had the entire spike protein detectable. However, the assay that was used to detect this S1 subunit and the spike protein itself in these 13 people has a false positivity rate of 25%. That's one in four people, showing they have spike protein. This was another study done, they took samples pre-pandemic, there should be no people with spike protein pre-pandemic, and they were showing that they had spike protein. So with a sample size of 13 and a false positivity rate of 25%, you can't make any conclusions from that small study showing, you know, that 11 out of 13 people had, you know, S1 subunit of spike protein showing up in the plasma. It just doesn't make any sense to make any strong conclusions from that. So, I guess that, you know, the bottom line is that, you know, as Roger mentioned, we've had over 177 million people fully vaccinated in the United States. You know, if this thing was causing severe damage in people, we would know about it. And, you know, we do know about the adverse effects that are occurring like the myocarditis that is happening, you know, in some young people. It's still quite rare. It does occur. And, again, as Roger mentioned, it's happening six-fold higher in younger healthy individuals than it is in the same individuals that are being exposed to the COVID-19 vaccines.
A test used in laboratory medicine, pharmacology, environmental biology, and molecular biology to determine the content or quality of specific components.
An infectious disease caused by the novel coronavirus SARS-CoV-2. COVID-19, or coronavirus disease 2019, was first identified in Wuhan, China, in late 2019. The disease manifests primarily as a lower respiratory illness, but it can affect multiple organ systems, including the cardiovascular, neurological, gastrointestinal, and renal systems. Symptoms include fever, cough, fatigue, shortness of breath, and loss of smell and taste. Some infected persons, especially children, are asymptomatic. Severe complications of COVID-19 include pneumonia, sepsis, acute respiratory distress syndrome, kidney failure, multiple organ dysfunction syndrome, and cytokine storm. Treatments currently involve symptom management and supportive care. Mortality varies by country and region, but approximately 6 percent of people living in the United States who are diagnosed with COVID-19 expire.[1] 1
An essential mineral present in many foods. Iron participates in many physiological functions and is a critical component of hemoglobin. Iron deficiency can cause anemia, fatigue, shortness of breath, and heart arrhythmias.
A chemical that causes Parkinson's disease-like symptoms. MPTP undergoes enzymatic modification in the brain to form MPP+, a neurotoxic compound that interrupts the electron transport system of dopaminergic neurons. MPTP is chemically related to rotenone and paraquat, pesticides that can produce parkinsonian features in animals.
A type of vaccine that contains the genetic material to encode a single viral protein that, when injected into the body, induces antibody production against the target protein. Because mRNA degrades easily, it must be encapsulated in lipid nanoparticles in order to be absorbed by cells and often must be delivered in multiple injections to promote optimal immune response.
The highest level of intake of a given nutrient likely to pose no adverse health effects for nearly all healthy people. As intake increases above the upper intake level, the risk of adverse effects increases.
Volatile organic compound. An organic chemical that has a high vapor pressure at ordinary room temperature.
Learn more about the advantages of a premium membership by clicking below.
The FoundMyFitness Q&A happens monthly for premium members. Attend live or listen in our exclusive member-only podcast The Aliquot.