What if someone told you the burger combo meal ordered ubiquitously from dive-thru windows around the world may have a worse effect on cardiovascular health than previously expected? The “Big Mac effect”, a colloquial term coined by Ronald Krauss, refers to this negative impact, which may become the focus of a full-fledged nutritional research study once funding is available. In this clip, Ronald Krauss discusses the negative combinative effect of consuming added sugars and saturated fat together.